Oral Contributions


Megan Stevens,PhD

Affiliation: School of Physiology and Pharmacology University of Bristol, Bristol (UK)
Title: Splicing-sensitive fluorescent reporter mice to assess splicing regulation and the effects of splicing regulatory compounds

Maria Spletter,PhD

Affiliation: Dept. of Physiological Chemistry Ludwig-Maximilians-Universität München, Munich (Germany)
Title: Scaf6 (DmCHERP) regulates muscle development and function in Drosophila

Nicholas Webster,PhD

Affiliation: University of California, San Diego (USA)
Title: Lipid excess causes loss of the splicing factor SRFS3 in NAFLD and NASH

Maayan Salton,PhD

Affiliation: Biochemistry and Molecular Biology Department The Institute for Medical Research Israel-Canada The Hebrew University Faculty of Medicine (Israel)
Title: Epigenetic regulation of alternative splicing in health and disease

Annemieke Aartsma-Rus,PhD

Affiliation: Leiden University Medical Center, Leiden (Netherlands)
Title: Antisense-mediated splicing modulation therapy development

Beatrice Eymin,PhD

Affiliation: Centre de Recherche UGA / INSERM U1209 / CNRS UMR5309 Institut Albert Bonniot (France)
Title: New functions of the splicing factor SRSF2 in DNA Damage Response

Marco A.M. Prado,PhD

Affiliation: The University of Western Ontario (Canada)
Title: Cholinergic Regulation of hnRNPA2/B1

Michael R. Ladomery,PhD

Affiliation: Faculty of Health and Applied Sciences University of the West of England (UK)
Title: Potent effect of the CLK1 inhibitor TG003 on prostate cancer cell growth

Jakob Biran,PhD

Affiliation: Institute of Animal Sciences Agricultural Research Organization (Israel)
Title: PAC1 Splicing Regulates Stress Related Behaviour in Zebrafish

Liliana Florea ,PhD

Affiliation: McKusick-Nathans Institute of Genetic Medicine Department of Medicine/GIM Johns Hopkins School of Medicine (USA)
Title: Simultaneous multi-sample analysis significantly improves alternative splicing detection

Jochen Reiss,PhD

Affiliation: University Medicine Göttingen, Gottingen (Germany)
Title: Alternative splicing in molybdenum cofactor deficiency: Problems and solutions in gene therapy

Michael Gotthardt, MD

Affiliation: Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin (Germany)
Title: Cardiac Splicing as a therapeutic target to improve diastolic function

Maria Costa,PhD

Affiliation: Institut de Biologie Intégrative de la Cellule (I2BC) CNRS, CEA, Univ Paris-Sud, Université Paris-Saclay, Paris (France)
Title: Crystal Structures of a Group II Intron Lariat: Implications for Nuclear pre-mRNA Splicing

Jonathan Morris,PhD

Affiliation: UNSW Sydney, Sydney (Australia)
Title: Development of Small Molecule Inhibitors of RNA Splicing Kinases

Lorna Harries,PhD

Affiliation: University of Exeter (UK)
Title: Altered mRNA processing in ageing and longevity

Alison Tyson-Capper,PhD

Affiliation: Institute of Cellular Medicine 3rd Floor, William Leech Building The Medical School Newcastle University (UK)
Title: Explaining why alternate splicing of the HER2 gene is so important for patients with breast cancer

Murray Cairns,PhD

Affiliation: School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine, Newcastle (UK)
Title: RNA splicing and the modulation of posttranscriptional regulation in schizophrenia

W.W.M. Pijnappel,PhD

Affiliation: Center for Lysosomal and Metabolic Diseases Erasmus Medical Center (Netherlands)
Title: GAA deficiency in Pompe disease is alleviated by exon inclusion in iPS cell-derived skeletal muscle cells

Mojgan Rastegar,PhD

Affiliation: University of Manitoba (Canada)
Title: Epigenetic control and alternative splicing of MECP2 isoforms in the brain

Will Fairbrother,PhD

Affiliation: Brown University (USA)
Title: The Second Life of Introns: annotating branchpoints and discovering functions of spliced introns.

Laura Elnitski,PhD

Affiliation: National Human Genome Research Institute National Institutes of Health (USA)
Title: Deciphering splicing mutations that coincide with positions of oncogenic driver mutations

Jimena Giudice,PhD

Affiliation: University of North Carolina at Chapel Hill (USA)
Title: Alternative splicing and intracellular interplay in development

Phil Potter,PhD

Affiliation: St. Jude Children’s Research Hospital (USA)
Title: Massive upregulation of alternative splicing by small molecules that target SF3B1

Sonia Forcales,PhD

Affiliation: Institute of Health Research Germans Trias i Pujol (IGTP), Can Ruti Campus, Badalona, Barcelona (Spain)
Title: Aberrant binding of RNA processing proteins to a novel macrosatellite-derived lncRNA in colorectal cancer

Paola Grandi,PhD

Affiliation: Cellzome GmbH, a GSK company (Germany)
Title: Click chemistry enables pre-clinical evaluation of BET inhibitor drugs

Cameron Mackereth,PhD

Affiliation: Inserm U1212 / Univ. Bordeaux Institut Européen de Chimie et Biologie, Bordeaux (France)
Title: MEC-8 regulated alternative splicing in neurons

Lourdes R Desviat,PhD

Affiliation: Universidad Autonoma de Madrid (Spain)
Title: Splicing mutations in neurometabolic diseases: mechanisms and therapies

Lingfang Zeng,PhD

Affiliation: King’s College, London (UK)
Title: A histone deacetylase 7-derived 7-amino- acid peptide acts as a phosphate group transporter

Katarzyna Taylor,PhD

Affiliation: Adam Mickiewicz University, Institute of Molecular Biology and Biotechnology, Laboratory of Gene Expression (Poland)
Title: Regulation of alternative splicing by MBNL

Přemysl Souček,PhD

Affiliation: CEITEC (Czech Republic)
Title: High throughput approach to identification of splicing regulatory elements in exon 7 of SMN1

Rahul Kanadia,PhD

Affiliation: University of Connecticut (USA)
Title: The role of minor splicing in regulation of alternative splicing in development and disease

Sean Porazinski Mres,PhD

Affiliation: Faculty of Health and Applied Sciences, University of the West of England (UK)
Title: Targeting the ERG oncogene with splicing switching oligonucleotides

Elisabetta Castoldi,PhD

Affiliation: Department of Biochemistry, Maastricht University (The Netherlands)
Title: Regulation of coagulation by alternative splicing

Luda Diatchenko, PhD

Affiliation: McGill University (Canada)
Title: Alternative Splicing of Four Opioid Receptor Genes Family Suggests an Existence of New Conserved Functional Receptor Isoforms with Unique Structure of mu Opiod Receptor MOR

Andy Berglund,PhD

Affiliation: College of Medicine University of Florida (USA)
Title: The splicing factors MBNL and RBFOX co-regulate alternative splicing through multiple mechanisms

James Hagman,PhD

Affiliation: Dept. of Biomedical Research National Jewish Health, University of Colorado (USA)
Title: Regulation of humoral immune responses by a novel regulator of alternative pre-mRNA splicing

Russ Carstens,PhD

Affiliation: University of Pennsylvania (USA)
Title: Arhgef11 regulates RhoA-MLC mediated epidermal tight junction integrity through an alternatively spliced isoform controlled by Esrp1

Sue Fletcher,PhD

Affiliation: Murdoch University Centre for Comparative Genomics (Australia)
Title: Antisense oligomer intervention increases PRPF31 expression in retinitis pigmentosa 11 studies

Elizabeth Bowler,PhD

Affiliation: University of Exeter Medical School (UK)
Title: Compounds and signalling mechanisms that regulate VEGF-Axxxb splice site selection

Przemyslaw Szafranski,PhD

Affiliation: Baylor College of Medicine (USA)
Title: Interrupted genes in mitochondria: a split cox2 and its expression


Francois Bernier, PhD

Affiliation: University of Calgary (Canada)
Title: Craniofacial spliceosomopathies


Heiner Schaal, PhD

Affiliation: Heinrich-Heine-Universität Düsseldorf (Germany)
Title: Towards understanding non-canonical 5’ splice site recognition


Peter Jordan, PhD

Affiliation: Departamento de Genética Humana, Instituto Nacional de Saúde Doutor Ricardo Jorge
Title: Regulation of alternative splicing of RAC1b by signal transduction pathways

Angshumonik Angbohang,PhD

Affiliation: King’s College London, London (UK)
Title: Role of XBP1 splicing in a novel type IV collagen isoform induction

Natasha Hill,PhD

Affiliation: Kingston University London, London (UK)
Title: The effects of metabolic conditions on alternative splicing

Roi Gazit,PhD

Affiliation: Ben-Gurion University of the Negev (Israel)
Title: Splicing in Hematopoietic Stem Cells

David Elliott,PhD

Affiliation: Newcastle University (UK)
Title: Single cell transcriptome diversity by alternative splicing in human

Atsushi Ogura,PhD

Affiliation: Nagahama Institute of Bioscience and Technology (Japan)
Title: Differential Alternative Splicing variants Estimation method without reference genome

Takahito Ohshiro,PhD

Affiliation: Osaka University, Osaka (Japan)
Title: Development of Single-Molecule Electrical RNA Identification Method

Jonathan Morris,PhD

Affiliation: UNSW Sydney, Sydney (Australia)
Title: Development of Small Molecule Inhibitors of RNA Splicing Kinases

Andriana Margariti,PhD

Affiliation: Queen’s University Belfast, Belfast (Ireland)
Title: Dynamic role of Quaking mRNA splicing in diabetes-related endothelial dysfunction

Silvia Buonamici,PhD

Affiliation: H3 Biomedicine (USA)
Title: Splicing modulators for the treatment of spliceosome-mutant cancers

Ivan Gorlov,PhD

Affiliation: Dartmouth College (USA)
Title: Evolution of splicing and its relevance to Genome Wide Association Studies (GWAS)

Valer Gotea,PhD

Affiliation: National Human Genome Research Institute (NHGRI) (USA)
Title: An Alternative Approach to Detect Differential Exon Usage in Large RNA-Seq Datasets

Ravindra Singh,PhD

Affiliation: College of Veterinary Medicine, Iowa State University (USA)
Title: Spinal muscular atrophy genes generate a vast repertoire of circular RNAs

Lucy Donaldson,PhD

Affiliation: University of Nottingham (UK)
Title: Developing systemically active spicing kinase SRPK1 inhibitors as anti-inflammatory/analgesic drugs

Natalia Singh,PhD

Affiliation: College of Veterinary Medicine, Iowa State University (USA)
Title: A novel role of engineered U1 snRNPs in splice site selection

Marie-Louise Hammarskjold,PhD

Affiliation: University of Virginia (USA)
Title: NXF1 and Intron Retention in Viruses and Cellular Genes

Rui Zhao,PhD

Affiliation: University of Colorado School of Medicine (USA)
Title: Structure and function of the yeast spliceosome

Luisa Escobar,PhD

Affiliation: Memorial Sloan Kettering Cancer Center (USA)
Title: Aberrant RNA splicing induced by mutant p53 promotes oncogenic RAS signaling

Zsuzsanna Izsvák,PhD

Affiliation: Max-Delbrück-Center for Molecular Medicine (Germany)
Title: PGBD1, a Domesticated PiggyBac-Derived Gene, has a neuroprotective Function

Nicoletta Potenza,PhD

Affiliation: University of Campania “L. Vanvitelli” (Italy)
Title: Regulating the Regulators: the multifaceted story of miR-125a

Wei Guo,PhD

Affiliation: Center for Cardiovascular Research and Alternative Medicine University of Wyoming (USA)
Title: Diverse Splicing Mode of a Giant Gene TTN and Its Splicing Regulation

Julián Cerón Madrigal, PhD

Affiliation: Bellvitge Biomedical Research Institute – IDIBELL Hospital Duran i Reynals (Spain)
Title: Modeling splicing-related diseases by mimicking human mutations in C. elegans using CRISPR

Ana Conesa, PhD

Affiliation: University of Florida (USA)
Title: Functional analysis of splicing differences between neural lineages with the tappAS tool reveals ubiquitous utilization of splicing for process regulation, but specific enrichment protein localization motifs

Annelies de Klein, PhD

Affiliation: Erasmus University Medical Center (Netherlands)
Title: Uveal Melanomas with SF3B1 Mutations: A Distinct Subclass Associated with Late-Onset Metastases

Ulrich Koller, PhD

Affiliation: University Hospital of the Paracelsus Medical University Salzburg, Salzburg (Austria)
Title: Col7A1 repair via RNA trans-splicing in a dystrophic epidermolysis bullosa mouse model

George A. Garinis, PhD

Affiliation: University of Crete (Greece)
Title: DNA damage and alternative splicing in development and disease

David Rekosh,PhD

Affiliation: University of Virginia (USA)
Title: RNA Export of Unspliced RNA as a Modulator of HIV Replication

Yann Audic,PhD

Affiliation: Institute Of Genetics And Development In Rennes, Rennes (France)
Title: Regulation of TP63 splicing

Gideon Grafi,PhD

Affiliation: Ben-Gurion University of the Negev (Israel)
Title: Epigenetic silencing of the exonic Evelknievel retroelement allows for its entire splicing out and reconstitution of CMT1 mRNA

Nuno Barbosa Morais,PhD

Affiliation: Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa (Portugal)
Title: CELF2 at the core of a prognostic alternative splicing signature in colorectal cancer

Sylvie Tuffery-Giraud,PhD

Affiliation: Laboratoire de Génétique de Maladies Rares, IURC (France)
Title: Splicing regulation in the Duchenne Muscular Dystrophy (DMD) gene

Cosima Rhein,PhD

Affiliation: University Hospital Erlangen, Department of Psychiatry and Psychotherapy (Germany)
Title: Alternative splicing of SMPD1, coding for acid sphingomyelinase, in major depression

Atze Bergsma,PhD

Affiliation: Erasmus MC (Netherlands)
Title: Unbiased detection and restoration of aberrant pre-mRNA splicing caused by different types of pathogenic variants in Pompe disease

Arvydas Kanopka,PhD

Affiliation: Institute of Biotechnology, Vilnius University, Vilnius (Lithuania)
Title: Cell lines possess differential splicing factor expression and tumor associated mRNA isoform formation profiles

Mikhail Skoblov,PhD

Affiliation: Research Centre for Medical Genetics (Russia)
Title: Pathogenicity analysis of nucleotide variants affecting pre-mRNA splicing in Mendelian disorders

Dorota Kaminska,PhD

Affiliation: University of Eastern Finland (Finland)
Title: Analysis of obesity-related alternative splicing in adipose tissue

Claude Houdayer,PhD

Affiliation: Institut Curie – Oncogenetics Head, Germline Genetics Laboratory, INSERM (France)
Title: Novel diagnostic tool for prediction of variant spliceogenicity derived from a set of 395 combined in silico/in vitro studies: an international collaborative effort

Ilaria Granata,PhD

Affiliation: ICAR-CNR (Italy)
Title: Comparative analysis of alternative splicing signatures among different in vitro models of breast cancer subtypes

Alexandre de Lencastre,PhD

Affiliation: Quinnipiac University (USA)
Title: Interactions between microRNAs and Splicing during C. elegans aging

Glenn A. Burley,PhD

Affiliation: University of Strathclyde (UK)
Title: Unravelling the molecular determinants of splice site selection with chemical biological tools

Benoit Cousineau,PhD

Affiliation: Department of Microbiology & Immunology (Canada)
Title: Bacterial group II introns generate genetic diversity at the RNA level by catalyzing intergenic trans-splicing

John S.D. Chan,PhD

Affiliation: Université de Montréal, Montréal (Canada)
Title: Heterogeneous Nucleus Ribonucleoprotein F (hnRNP F) Regulates Intrarenal Renin-Angiotensin System Genes Transcription and Systemic Hypertension in Diabetes

Liliana Matos,PhD

Affiliation: Instituto Nacional de Saúde Dr. Ricardo Jorge (Portugal)
Title: Development of an antisense-mediated exon skipping therapeutic strategy to correct a frequent causing mutation in Mucolipidosis II

Shao-Ling Zhang,PhD

Affiliation: University of Montréal, Montréal (Canada)
Title: Heterogeneous Nuclear Ribonucleoprotein F Deficiency Aggravates Podocyte Loss via Modulating Alternative Splicing of Insulin Receptor Gene in Adriamycin-Induced Nephropathy in Mice

Raul M. Luque,PhD

Affiliation: University of Córdoba, Córdoba (Spain)
Title: Available Soon.

Justo P. Castaño,PhD

Affiliation: University of Córdoba, Córdoba (Spain)
Title: Available Soon.

Manuel D. Gahete,PhD

Affiliation: University of Córdoba, Córdoba (Spain)
Title: The expression of splicing machinery components can predict the development of type 2 diabetes in high-risk patients: influence of dietary intervention

David J Fitzgerald,PhD

Affiliation: Henry Ford Hospital, Integrative Biosciences Center (USA)
Title: The use of an RNA-based CRISPR approach to correct aberrant RNA splicing in cells from an individual with X-linked myotubular myopathy

Sophia Adamia,PhD

Affiliation: Dana-Farber Cancer Institute & HMS Medical Oncology (USA)
Title: Aberrant splicing in patients with myeloma is associated with modulated expression of PTBPs

Leslie Sutherland,PhD

Affiliation: Health Sciences North Researche Institute (Canada)
Title: Identification of a complex mechanistic relationship between two related RNA binding proteins in a small cell lung cancer model

Usha Vijayraghavan,PhD

Affiliation: Indian Institute of Science (India)
Title: Functions for fission yeast splicing factors in pre-mRNA splicing, alternative splice-site choice and stress-regulated splicing

Xavier Roca Castella,PhD

Affiliation: Nanyang Technological University (Singapore)
Title: BIM alternative splicing as a determinant of drug responses in tyrosine kinase driven cancers

Julie Loiselle,PhD

Affiliation: Health Sciences North Researche Institute (Canada)
Title: Determination of the mechanistic basis of the antagonistic functions of RBM5 and RBM10